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Search Results for " serum binding protein "

Targets Recommended: Others

7

抑制剂 & 化合物

1

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2298L	transferrin fragment acetate	Others	Others
	transferrin fragment acetate 是动物血清中主要的铁结合蛋白，其铁结合位点和性质类似于乳铁蛋白1。
TP2302	vitamin D binding protein precursor (353-363) [Homo sapiens]	Others	Others
	Human vitamin D-binding protein (hDBP) is an abundant, multifunctional, and highly polymorphic serum glycoprotein synthesized by the liver1.
TP2298	transferrin fragment	Others	Others
	Transferrin is the principal iron-binding protein in animal serum and is analogous in its iron-binding site and properties to lactoferrin1. Human transferrin is a single-chain glycoprotein of molecular weight near 80,000. The molecule is arranged in two l
TP2190	vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]	Others	Others
	Vitamin D-binding protein is a multifunctional, highly expressed, polymorphic serum protein. These range from the transport of vitamin D metabolites to possible roles in the immune system and host defense. The molecular weight range, the time course of ap
T32288	JH-IX-179 JH-IX179,JH-IX 179
	JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autoph
T77058	Lerodalcibep
	Lerodalcibep (LIB003) 是一种重组融合蛋白，由PCSK9结合域 (adnectin) 与人血清白蛋白组成。作为降脂剂，Lerodalcibep 适用于高胆固醇血症和心血管疾病的研究。
T83770	Klotho-derived Peptide 1 (56-87) (human) TFA KP1 (56-87)
	Klotho衍生肽1（KP1）(56-87)是从人类Klotho蛋白质中衍生的肽，具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1（TGFBR2）和TGF-β受体类型2（TGFBR2；Kds分别为1.41和14.6µM）结合。KP1（10 µg/ml）的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白（α-SMA）水平的增加。在体内，KP1（每天1 mg/kg）选择性地定位于受损的肾脏，并减少血清肌酐和血尿素氮水平，这些是肾功能的标志物，同时也减少了小鼠单侧输尿管阻塞（UUO）和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。

化合物

transferrin fragment acetate

Cat.No: TP2298L

Target: Others

vitamin D binding protein precursor (353-363) [Homo sapiens]

Cat.No: TP2302

Target: Others

transferrin fragment

Cat.No: TP2298

Target: Others

vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]

Cat.No: TP2190

Target: Others

Cat.No: T32288

Synonym: JH-IX179,JH-IX 179

Cat.No: T77058

Klotho-derived Peptide 1 (56-87) (human) TFA

Cat.No: T83770

Synonym: KP1 (56-87)

Cat. No.	Product Name	Target	Signaling Pathways
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。

天然产物

Norbixin hydrate

Cat.No: T83915

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00356	GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc) GHBP,GHR,Somatotropin receptor,growth hormone receptor,growt...	Mouse	HEK293 Cells
	Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its receptor in its extracellular domain. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway lead...
TMPY-03456	SRFBP1 Protein, Human, Recombinant (His & GST) STRAP,BUD22,P49,serum response factor binding	Human	Baculovirus Insect Cells
	SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRF...
TMPY-00105	Recombinant Protein G		E. coli
	Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig...
TMPH-00275	ITIH2 Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. ITIH2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 21.3 kDa and the accession number is P56651.
TMPH-02730	ITIH2 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. ITIH2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 79.6 kDa and the accession number is Q61703.
TMPJ-00133	MBL2 Protein, Mouse, Recombinant Mannose binding lectin (C),MBL-2,Mannose-bindin...	Mouse	HEK293 Cells
	Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum, it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria, fungi, protozoa and viruses and acts as an acute-phas...
TMPH-03371	Transferrin Protein, Rat, Recombinant (His & KSI)	Rat	E. coli
	Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Transferrin Protein, Rat, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight ...
TMPH-03326	MASP2 Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. MASP2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is Q9JJS8.
TMPJ-00523	SAA2 Protein, Human, Recombinant (His) SAA2,SAA,Serum Amyloid A2	Human	E. coli
	Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA...
TMPJ-00805	Apolipoprotein E/APOE Protein, Mouse, Recombinant (His) Apo-E,APOE,Apolipoprotein E	Mouse	HEK293 Cells
	Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium.
TMPJ-01118	GNMT Protein, Human, Recombinant (His) GNMT,Glycine N-Methyltransferase	Human	E. coli
	Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau...
TMPJ-00990	S100B Protein, Mouse, Recombinant (His) S-100 protein subunit beta,S-100 protein b...	Mouse	E. coli
	S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal flui...
TMPY-01659	SDPR Protein, Mouse, Recombinant (aa 2-180, His) serum deprivation response	Mouse	E. coli
	Serum deprivation-response protein, also known as Phosphatidylserine-binding protein, Cavin-2 and SDPR, is a member of the PTRF / SDPR family. SDPR is highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle. SDPR is a new regulator of caveolae biogenesis. SDPR is up-regulated in asynchronously growing fibroblasts following serum deprivation but not following contact inhibition and Down-regulated during synchronous cell cy...
TMPJ-00751	IgG4 hFc Protein, Human, Recombinant (aa 99-326) IgG4 Fc,Ig γ-4 chain C region,Ig gamma-4 chain C region	Human	HEK293 Cells
	As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetram...
TMPJ-01137	MIA Protein, Human, Recombinant (His) MIA,Melanoma Inhibitory Activity Protein,Melanoma-D...	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au...
TMPY-01875	SCGN Protein, Human, Recombinant (His) SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calcium <...	Human	E. coli
	Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ...

重组蛋白

GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00356

Species: Mouse

Expression System: HEK293 Cells

SRFBP1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03456

Species: Human

Expression System: Baculovirus Insect Cells

Recombinant Protein G

Cat.No: TMPY-00105

Expression System: E. coli

ITIH2 Protein, Bovine, Recombinant (His & KSI)

Cat.No: TMPH-00275

Species: Bovine

Expression System: E. coli

ITIH2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02730

Species: Mouse

Expression System: E. coli

MBL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00133

Species: Mouse

Expression System: HEK293 Cells

Transferrin Protein, Rat, Recombinant (His & KSI)

Cat.No: TMPH-03371

Species: Rat

Expression System: E. coli

MASP2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03326

Species: Rat

Expression System: Baculovirus Insect Cells

SAA2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00523

Species: Human

Expression System: E. coli

Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00805

Species: Mouse

Expression System: HEK293 Cells

GNMT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01118

Species: Human

Expression System: E. coli

S100B Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00990

Species: Mouse

Expression System: E. coli

SDPR Protein, Mouse, Recombinant (aa 2-180, His)

Cat.No: TMPY-01659

Species: Mouse

Expression System: E. coli

IgG4 hFc Protein, Human, Recombinant (aa 99-326)

Cat.No: TMPJ-00751

Species: Human

Expression System: HEK293 Cells

MIA Protein, Human, Recombinant (His)

Cat.No: TMPJ-01137

Species: Human

Expression System: E. coli

SCGN Protein, Human, Recombinant (His)

Cat.No: TMPY-01875

Species: Human

Expression System: E. coli

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